Dr. Ken Chen is currently a tenured associate professor in department of Bioinformatics and Computational Biology at MD Anderson Cancer Center in Houston, TX. He received a B.E. degree from Tsinghua University, China (Precision Instruments, 1996), a Ph.D. from University of Illinois at Urbana-Champaign (Electrical and Computer Engineering, 2004) and postdoctoral training from University of California, San Diego (Biophysics and Biochemistry, 2005). He also worked as a visiting researcher in Microsoft Research Asia (2001) and in Johns Hopkins University (Center for Language and Speech Processing, 2004). From 2005 to 2011, he worked for the Genome Institute at Washington University in St. Louis as a senior scientist and a research faculty. Having a background in machine learning, statistical signal processing, bioinformatics, and genomics, his primary interest is to develop computational tools to analyze and interpret human genomics and clinical data towards the realization of genomic medicine. Dr. Chen has designed, developed, and co-developed a set of computational tools such as BreakDancer, BreakTrans, BreakFusion, TIGRA, CREST, PolyScan, SomaticSniper, and VarScan, which have been widely applied to characterize individual and population genomics in various large-scale sequencing projects such as those in The Cancer Genome Atlas (TCGA) and the 1000 Genomes Project. He is particularly interested in comprehensively and accurately constructing the genomes and the transcriptomes of various cancer cell populations with a focus on structural variants, towards understanding the heterogeneity and the evolution of cancer as a consequence of the genetics and the environment. He is also interested in correlating genomics with diseases towards identifying biomarkers that are useful for personalized diagnosis and prognosis.