New target identification using genetics, genomics, bioinformatics and network biology in neurodegeneration and psychiatry. Target annotation and ranking. RNAseq, array expression and epigenetic analysis of human brain. eQTLs. Genetic mapping. Systems biology approaches to understanding biological networks in brain disorders. Cheminformatics. Drug discovery using network-based gene expression changes to generate drug signatures. Pharmacoepidemiology and real world evidence data mining in drug discovery.