Paul Macklin is a mathematician and an Associate Professor of Intelligent Systems Engineering at Indiana University. He is developing a “virtual laboratory” to help scientists assess and engineer the systems-level effects of current and emerging cancer treatments by simulating how cells interact in 3-D tissues. Dr. Macklin uses a highly collaborative, open source / open science approach to accelerate this work while building cross-disciplinary, multi-institutional teams that pool expertise to create shared mathematical and computational tools.
Dr. Macklin founded and leads several open source projects, including PhysiCell (simulates many cells as they interact in 3-D tissues), BioFVM (solves for diffusion of signaling factors, oxygen, and drugs), and MultiCellDS (standards for sharing multicellular data). These tools have been applied to primary and metastatic breast cancer, metastases in liver tissue, and most recently cancer immunology. To learn more, visit http://OpenSource.MathCancer.org.