Through my PhD training at Dartmouth and early postdoc training at Harvard Medical School, I developed functional spectroscopy and single cell imaging methods to couple single cell dynamics with population phenotype. When family obligations necessitated a move to NYC, I embraced the opportunity to better understand cell signaling and cancer metastasis in the lab of Dr. Joan Massagué. Here, I have translated my skills to discover mechanisms that critically regulate maintenance and evolution of latent metastasis by extracting biological patterns from high-throughput measures of single-cell transcriptional heterogeneity. As a complimentary strategy, I track individual cell response to molecular perturbations by live cell imaging in vivo. By integrating the field of cancer metastasis with single cell transcriptomic/image analysis and mathematical modeling of cell-cell interactions, I aim to discover how heterogeneity among individual cancer cells shapes lethal transitions like metastasis and the emergence of drug resistance.