phase: I grants: U01MH103392 tissue: dorsolateral prefrontal cortex methods: syn12207447 species: Human dataTypes: Chromatin Activity diagnosis: Schizophrenia studyType: Individual relatedStudies: syn4566010 syn12080241 studyDescription: The EpiDiff study compares frontal lobe epigenetic variation – specifically histone modifications characterized by promoter and enhancer marks – in individuals diagnosed with schizophrenia and in neurotypical controls. The resulting epigenetic maps provide a basis for investigating the relationship between regulatory histone modification landscapes and genetic risk factors for schizophrenia. nucleicAcidSource: bulk nuclei numberOfIndividuals: 327 contributingInstitution: Icahn School of Medicine at Mt.Sinai syn25710588