Q: Am I correct in thinking that we can use the 84 genes to obtain the gold standard and train the models in sub-challenge1, 2 and 3. But we are not allowed to build a classifier using 20 genes to predict 84 genes and build the model? And are we not allowed to use the 84 genes' gene expression either, but allowed to use other (except the 84 marker genes) gene's expression? A: Yes and you can use all gene expression but not the in situ information for all 84.