Why would a drug binding to a target have different KDs?
For instance, looking at CHEMBL135581 and P00374, I see several different KDs for the same interaction ranging from sub nano-molar to micro molar.
Created by Jeremy Jacobsen jjacob_cub Each of those Kds represent an individual experimental finding. One explanation for variability could be different labs, performing the experiment in different conditions, with different batches of reagents. It is up to you to decide whether and how to aggregate or filter these values.