I saw some records that have a KDAPP in the DTC. Is KDAPP another name for KD?
Created by Xiaokang Wang XiaokangWang Hi,
Kdapp values come from the following work: [The target landscape of clinical kinase drugs](https://www.ncbi.nlm.nih.gov/pubmed/29191878) by Klaeger et al.
Given E as the enzyme, I as the inhibitor and EI as the enzyme-inhibitor complex, Kd and Kdapp (apparent Kd) are defined as follows:
EI -> E + I,
Kd = [E][I] /[EI],
Kdapp = Kd/p,
where p is the number of molecules of the inhibitor per each molecule of enzyme-inhibitor complex.
Please feel free to use in the model training also other than Kd bioactivity types.