What approaches can be used to characterize the functional state of individual cells within a solid tumor?
Created by Laura Heiser lmheiser We use computational deconvolution methods to infer cell-type-specific gene expression profiles from the bulk tissue transcriptomes. It would be interesting to integrate image data and deconvolution methods. Our lab is experimenting with image acquisition and analysis tools - both in characterizing protein localization as well as observing higher level features, such as the organization and spatial orientation of tissues.
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