What are the key genetic, epigenetic, and phenotypic sources of intratumoral heterogeneity?
Created by Laura Heiser lmheiser Whole exome sequencing is ideal for identifying subclonal populations of cells within a sample.
Mitochondrial reads have been shown to be useful for developing phylogenetic trees from single cell sequencing as well.
I have considered using ATACsequencing to profile subclonal populations but i don't have data on this.
snATAC/RNAseq would be useful epigenetic and phenotypic sources for studying intratumoral heterogeneity though. We are working on this front but have limited data on this.
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