NF1 is a disease in the RASopathy family of diseases, which include Costello Syndrome, Noonan Syndrome, and Cardiofaciocutaneous syndrome. (Knowing that it is a RASopathy may provide some structural/transfer learning insight.) A unified model of NF1 should explain these complications. Most of these have recently been reproduced in a single [pig model](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168575/). Being able to reproduce the full spectrum of human complications in a single rapid-growth animal model should help to rapidly accelerate unified modelling. Here is a recap of the NF1 complications listed in the [NF1 Wikipedia article](https://en.wikipedia.org/wiki/Neurofibromatosis_type_I):
* Attention deficit hyperactivity disorder
* Bowing of a long bone with a tendency to fracture and not heal, yielding a pseudarthrosis
* Chronic pain, numbness, and paralysis due to peripheral nerve sheath tumor
* Cystic diverticula of the dura of the spine (termed meningoceles. This meningocele is not related to spina bifida).
* Dermal neurofibroma
* Dural ectasia
* Epilepsy
* Flat pigmented lesions of the skin called Café au lait spot
* Focal scoliosis and/or kyphosis
* Focally degenerative myelin leading to UBOs
* Freckling of the axillae or inguinal regions.
* Glial tumors of the central nervous system
* Lisch nodules in the iris
* Malformation of the facial bones or of the eye sockets (lambdoid suture defects, sphenoid dysplasia)
* Malignant peripheral nerve sheath tumor
* Meningoceles and formation of cystic diverticula of the dura of the spine
* Mesodermal dysplasia
* Motor deficits
* Muscle weakness
* Musculoskeletal abnormalities affecting the skull include Sphenoid bone dysplasia, Congenital Hydrocephalus
* Myopathy
* Nerve root neurofibroma
* Neural foramen of the vertebral column can be widened due to the presence of a nerve root neurofibroma or schwannoma
* Optic gliomas along one or both optic nerves or the optic chiasm
* Peripheral nerve-sheath tumors
* Plexiform Neurofibroma
* [Precocious puberty](https://www.ncbi.nlm.nih.gov/pubmed/10969931)
* Reduced skeletal muscle size
* Renal artery anomalies or pheochromocytoma and associated chronic hypertension
* Ribs can develop chronic erosions from the constant pressure of adjacent neurofibroma or Schwannoma
* Schwannoma
* Solitary neurofibroma in a deep nerve trunk
* Spatial deficit
* Speech and language delays
* Unilateral overgrowth of a limb