title: Somatic Mosaicism in the brain of Tourette syndrome abstract: Somatic mosaicism arising in brain cells could explain the failure to discover consistent, replicable genetic risk factors in neuropsychiatric disorders like TS. To test the hypothesis that somatic mutations might underlie the emergence of TS, in this proposal wel discover and quantify somatic genome variation in TS and normal control brains, followed by exploration of potential functional consequences of this variation. grantNumber: U01MH106876 institution: Yale University institutions: Yale University projectTitle: Somatic Mosaicism in the brain of Tourette syndrome ndaCollection: [2961](https://nda.nih.gov/edit_collection.html?id=2961) primaryInvestigator: Flora Vaccarino, Alexej Abyzov, Alexander Urban primaryInvestigators: Flora Vaccarino Alexej Abyzov Alexander Urban
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