url: https://www.jax.org/strain/008730 data: UCI_5XFAD Jax.IU.Pitt_5XFAD Jax.IU.Pitt_Levetiracetam_5XFAD grant: U54AG054345 program: MODEL-AD species: Mouse summary: 5XFAD transgenic mice overexpress both mutant human APP(695) with the Swedish (K670N, M671L), Florida (I716V), and London (V717I) Familial Alzheimer’s Disease (FAD) mutations and human PS1 harboring two FAD mutations, M146L and L286V. Expression of both transgenes is regulated by neural-specific elements of the mouse Thy1 promoter to drive overexpression in the brain. These 5XFAD transgenic mice rapidly recapitulate major features of Alzheimer’s Disease amyloid pathology. AlzForum: [Link](https://www.alzforum.org/research-models/5xfad-c57bl6) toolType: Mouse Model modelType: Familial Alzheimer's disease availableData: 5XFAD strainDetails: [View](https://www.jax.org/strain/008730) targetedGenes: APP PSEN1 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/5xfad-c57bl6)