url: https://www.jax.org/strain/005864 data: Jax.IU.Pitt_APP.PS1 grant: U54AG054345 program: MODEL-AD species: Mouse summary: APP/PS1 are double transgenic mice expressing a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe) and a mutant human presenilin 1 (PS1-dE9), both directed to CNS neurons by the mouse Prion promoter. Both mutations are associated with early-onset (familial) Alzheimer's disease. These mice may be useful in studying neurological disorders of the brain, specifically Alzheimer's disease, amyloid plaque formation and aging. AlzForum: [Link](https://www.alzforum.org/research-models/appswepsen1de9-c57bl6) toolType: Mouse Model modelType: Familial Alzheimer's disease contributor: David R Borchelt availableData: APPPS1 strainDetails: [View](https://www.jax.org/strain/005864) targetedGenes: APP PSEN1 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/appswepsen1de9-c57bl6)