url: https://www.jax.org/strain/005491 grant: U54AG054345 program: MODEL-AD species: Mouse summary: htau mice lack endogenous microtubule-associated protein tau (Mapt) gene expression, and express all six isoforms (including both 3R and 4R forms) of human MAPT (H1 haplotype). These mutant mice may be useful in studies examining the relationship between human MAPT and Alzheimer's disease pathogenesis. AlzForum: [Link](https://www.alzforum.org/research-models/htau) toolType: Mouse Model modelType: Familial Alzheimer's disease contributor: Karen Duff Peter Davies availableData: hTau strainDetails: [View](https://www.jax.org/strain/005491) targetedGenes: MAPT backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/htau)