url: https://www.jax.org/strain/030670 grant: U54AG054345 program: MODEL-AD species: Mouse summary: hAbeta/APOE4/Trem2*R47H is a triple mutant strain carrying a humanized ApoE knock-in mutation (sequence coding for isoform E4), a CRISPR/Cas9-generated App allele with a humanized Abeta1-42 region (G601R, F606Y, R609H in the mouse gene, corresponding to amino acid positions 676, 681, 684 in the human APP locus) and a CRISPR/Cas9-generated R47H point mutation of the mouse Trem2 gene. This model is used as a sensitized background to introduce additional genetic variants. AlzForum: [Link](https://www.alzforum.org/research-models/happapoe4trem2r47h) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner availableData: hAPPAPOE4Trem2R47H strainDetails: [View](https://www.jax.org/strain/030670) targetedGenes: APP APOE TREM2 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/happapoe4trem2r47h)