url: https://www.jax.org/strain/028709 data: Jax.IU.Pitt_APOE4.Trem2.R47H Jax.IU.Pitt_PrimaryScreen grant: U54AG054345 program: MODEL-AD species: Mouse summary: This double mutant strain carries a humanized ApoE knock-in mutation (sequence coding for isoform E4) and a CRISPR/cas9-generated R47H point mutation of the mouse Trem2 gene. This model is used as a sensitized background to introduce additional genetic variants associated with late-onset Alzheimer’s disease. toolType: Mouse Model modelType: Late Onset Alzheimer's disease isFeatured: true contributor: Mike Sasner availableData: APOE4Trem2R47H strainDetails: [View](https://www.jax.org/strain/028709) targetedGenes: APOE TREM2 backgroundStrain: C57BL/6J