url: https://www.jax.org/strain/030283 data: Jax.IU.Pitt_PrimaryScreen Jax.IU.Pitt_StrainValidation grant: U54AG054345 program: MODEL-AD species: Mouse summary: This model expresses a CRISPR/cas9-generated knock-in of an Alzheimer’s disease risk variant in the Abca7 gene: GCT>GGT, changing the alanine to glycine at position 1541 in exon 33 of the mouse locus. This is homologous to position 1527 in the human locus, and models the rs3752246 SNP risk SNP. This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. AlzForum: [Link](https://www.alzforum.org/research-models/abca7a1527gapoe4trem2r47h) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner availableData: Abca7A1527GAPOE4Trem2R47H strainDetails: [View](https://www.jax.org/strain/030283) targetedGenes: APP APOE TREM2 ABCA7 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/abca7a1527gapoe4trem2r47h)