url: https://www.jax.org/strain/027894 data: Jax.IU.Pitt_PrimaryScreen Jax.IU.Pitt_APOE4.Trem2.R47H grant: U54AG054345 program: MODEL-AD species: Mouse summary: This model expresses exons 2-4 of the human APOE gene knocked into the mouse Apoe locus. The Alzheimer’s disease risk variant APOE4 is expressed. AlzForum: [Link](https://www.alzforum.org/research-models/apoe4-knock-jax) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner availableData: APOE4KI strainDetails: [View](https://www.jax.org/strain/027894) targetedGenes: APOE backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/apoe4-knock-jax)