url: https://www.jax.org/strain/030670 grant: U54AG054345 program: MODEL-AD species: Mouse summary: A CRISPR/Cas9-generated App allele with a humanized Abeta1-42 region (G601R, F606Y, R609H in the mouse gene, corresponding to amino acid positions 676, 681, 684 in the human APP locus) is expressed. AlzForum: [Link](https://www.alzforum.org/research-models/happapoe4trem2r47h) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner availableData: hAPPAPOE4Trem2R47H strainDetails: [View](https://www.jax.org/strain/030670) targetedGenes: APP backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/happapoe4trem2r47h)