url: https://www.jax.org/strain/033668 grant: U54AG054345 program: MODEL-AD species: Mouse summary: • The MAPT(H2)-GR (genome replacement) mice contain a syntenic 190 kb region from human chr 17 (HSA17) that includes SPPLC2 and MAPT. The region replaces 157 kb on mouse chromosome 11. The SPPL2C sequence is included because it is embedded entirely in the MAPT-AS1 transcribed region. Homozygous mice are viable and fertile and exhibit no obvious phenotype. These mice express the human MAPT of the H2 haplotype and MAPT-AS1 transcripts and the typical MAPT protein isoforms. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Michael Koob strainDetails: [View](https://www.jax.org/strain/033668) targetedGenes: MAPT backgroundStrain: C57BL/6J