url: https://www.jax.org/strain/029725 grant: U54AG054345 program: MODEL-AD species: Mouse summary: This CRISPR/Cas9-generated knock-out mutant of the Trem2, triggering receptor expressed on myeloid cells 2, gene introduces a Y38C point mutation. The targeted Trem2 gene encodes a protein that is part of a receptor signaling complex with TYRO protein tyrosine kinase binding protein, and that activates macrophages and dendritic cells during immune responses. Loss-of-function variants of the TREM2 gene are associated with Alzheimer's Disease. AlzForum: [Link](https://www.alzforum.org/research-models/trem2-y38c-ki) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Bruce Lamb strainDetails: [View](https://www.jax.org/strain/029725) targetedGenes: TREM2 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/trem2-y38c-ki)