url: https://www.jax.org/strain/030320 grant: U54AG054345 program: MODEL-AD species: Mouse summary: This model expresses a CRISPR/cas9-generated knock-out of the Abca7 gene (a 33bp deletion in exon 32) and can be used to study rare loss of function variants that confer AD risk. This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. AlzForum: [Link](https://www.alzforum.org/research-models/abca7-koapoe4trem2r47h) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner strainDetails: [View](https://www.jax.org/strain/030320) targetedGenes: ABCA7 APOE TREM2 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/abca7-koapoe4trem2r47h)