url: https://www.jax.org/strain/030673 data: Jax.IU.Pitt_PrimaryScreen Jax.IU.Pitt_StrainValidation grant: U54AG054345 program: MODEL-AD species: Mouse summary: This model expresses a CRISPR/cas9-generated knock-out of the first exon of the Ceacam1 gene. This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. AlzForum: [Link](https://www.alzforum.org/research-models/ceacam1-koapoe4trem2r47h) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner availableData: Ceacam1KO strainDetails: [View](https://www.jax.org/strain/030673) targetedGenes: CEACAM1 APOE TREM2 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/ceacam1-koapoe4trem2r47h)