url: https://www.jax.org/strain/031944 data: Jax.IU.Pitt_StrainValidation grant: U54AG054345 program: MODEL-AD species: Mouse summary: This model expresses a CRISPR/cas9-generated L163P point mutation (CTG-->CCA) of the Clasp2 gene, which is a highly conserved missense variant (rs61738888) associated with late-onset AD risk. This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. AlzForum: [Link](https://www.jax.org/strain/031944) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner availableData: Clasp2L163PSNP strainDetails: [View](https://www.jax.org/strain/031944) targetedGenes: CLASP2 APOE TREM2 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.jax.org/strain/031944)