url: https://www.jax.org/strain/027713 grant: U54AG054345 program: MODEL-AD species: Mouse summary: These knock-in/knock-out mice express human CR2 and CR1 (and the intergenic region between the genes) from the endogenous mouse Cr2 locus. LoxP and FRT sites were included within the CR1 gene to allow for the generation of multiple splice forms of CR1 (CR1-long or -short), and the ability to generate a CR1 knockout leaving human CR2 intact. Variants in human CR1 are risk factors for late-onset AD. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Gareth Howell strainDetails: [View](https://www.jax.org/strain/027713) targetedGenes: CR2 APOE TREM2 backgroundStrain: C57BL/6J