url: https://www.jax.org/strain/031668 data: Jax.IU.Pitt_PrimaryScreen Jax.IU.Pitt_StrainValidation grant: U54AG054345 program: MODEL-AD species: Mouse summary: These KI/KO express human CR2 and CR1 from the endogenous mouse Cr2 locus. LoxP and FRT sites were included within the CR1 gene to allow for the generation of multiple splice forms of CR1 (CR1-long or -short), and the ability to generate a CR1 KO leaving human CR2 intact. Variants in human CR1 are risk factors for LOAD. This is expressed on a sensitized model also expressing a humanized APOE4 KI and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. AlzForum: [Link](https://www.alzforum.org/research-models/hcr1-ki-apoe4trem2) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Gareth Howell strainDetails: [View](https://www.jax.org/strain/031668) targetedGenes: CR2 APOE TREM2 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/hcr1-ki-apoe4trem2)