url: https://www.jax.org/strain/030304 data: Jax.IU.Pitt_PrimaryScreen Jax.IU.Pitt_StrainValidation grant: U54AG054345 program: MODEL-AD species: Mouse summary: This model has a CRISPR/cas9-generated 387bp deletion in the first coding exon (exon 2) of the Il1rap gene. Due to alternative splicing, significant protein expression is still observed. The IL1RAP intronic variant rs12053868 is associated with amyloid accumulation in the ADNI cohort. This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene AlzForum: [Link](https://www.alzforum.org/research-models/il1rap-koapoe4trem2r47h) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner availableData: Il1rapKO strainDetails: [View](https://www.jax.org/strain/030304) targetedGenes: IL1RAP APOE TREM2 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/il1rap-koapoe4trem2r47h)
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