url: https://www.jax.org/strain/031938 data: Jax.IU.Pitt_StrainValidation grant: U54AG054345 program: MODEL-AD species: Mouse summary: This triple mutant strain carries a CRISPR/Cas9-generated T82T (ACA->ACG) point mutation of the Kif21b gene, to serve as a model to study the highly conserved synonymous KIF21B AD risk variant rs7556510. This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. AlzForum: [Link](https://www.alzforum.org/research-models/kif21bt82tapoe4trem2r47h) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner availableData: Kif21bT82TSNP strainDetails: [View](https://www.jax.org/strain/031938) targetedGenes: KIF21b APOE TREM2 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/kif21bt82tapoe4trem2r47h)