url: https://www.jax.org/strain/033770 data: Jax.IU.Pitt_StrainValidation grant: U54AG054345 program: MODEL-AD species: Mouse summary: Copy number variations in MEOX2 have been associated with early and severe forms of AD, and Meox2 haploinsufficiency has been shown to increase neurodegeneration in an AD mouse model. A heterozygous Meox2 knockout is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner strainDetails: [View](https://www.jax.org/strain/033770) targetedGenes: MEOX2 APOE TREM2 backgroundStrain: C57BL/6J