url: https://www.jax.org/strain/031950 data: Jax.IU.Pitt_StrainValidation grant: U54AG054345 program: MODEL-AD species: Mouse summary: CRISPR/Cas9 was used to engineer a point mutation (GTG->GGG) in the Mtmr4 gene to create the V297G amino acid substitution, to model the late-onset AD risk variant rs2302189 AD risk SNP. This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner strainDetails: [View](https://www.jax.org/strain/031950) targetedGenes: MTMR4 APOE TREM2 backgroundStrain: C57BL/6J