url: https://www.jax.org/strain/030771 grant: U54AG054345 program: MODEL-AD species: Mouse summary: CRISPR/Cas9 was used to engineer a point mutation (C>G at nucleotide 1565) to create the P522R amino acid substitution. This serves a model for a rare coding variant (Rs72824905) that is protective for AD. This variant is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner strainDetails: [View](https://www.jax.org/strain/030771) targetedGenes: PLCG2 APOE TREM2 backgroundStrain: C57BL/6J