url: https://www.jax.org/strain/031952 grant: U54AG054345 program: MODEL-AD species: Mouse summary: CRISPR/Cas9 was used to engineer a point mutation (GTGATG) into the mouse Shc2 gene to create the V433M amino acid substitution. This models the V577M variant (rs61749990) that is significantly associated with late-onset AD. This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner strainDetails: [View](https://www.jax.org/strain/031952) targetedGenes: SHC2 APOE TREM2 backgroundStrain: C57BL/6J