url: https://www.jax.org/strain/031948 grant: U54AG054345 program: MODEL-AD species: Mouse summary: CRISPR/Cas9 was used to engineer a silent point mutation (CCA->CCG) at amino acid residue 61 in the mouse Slc6a17 locus. This models the rs41281364 SNP that has been shown to be associated with late-onset AD risk. This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner strainDetails: [View](https://www.jax.org/strain/031948) targetedGenes: SLC6A17 APOE TREM2 backgroundStrain: C57BL/6J