url: https://www.jax.org/strain/031942 data: Jax.IU.Pitt_StrainValidation grant: U54AG054345 program: MODEL-AD species: Mouse summary: CRISPR/Cas9 was used to engineer the D465N mutation (GACAAC) into the mouse Snx1 gene (note that human and mouse numbering differ by a single amino acid). This models a common missense variant (rs1802376) in SNX1 which has been associated with late-onset AD in multiple independent cohorts. This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. AlzForum: [Link](https://www.alzforum.org/research-models/snx1d465napoe4trem2r47h) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner availableData: Snx1D465NSNP strainDetails: [View](https://www.jax.org/strain/031942) targetedGenes: SNX1 APOE TREM2 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/snx1d465napoe4trem2r47h)