url: https://www.jax.org/strain/031940 grant: U54AG054345 program: MODEL-AD species: Mouse summary: CRISPR/Cas9 was used to engineer a point mutation (GCCACC) into the mouse Sorl1 gene to create the A528T amino acid substitution. This models a common, highly conserved missense variant (rs2298813) that is significantly associated with late-onset AD. Overexpression of the missense variant rs2298813 leads to elevated Ab42 secretion. This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. AlzForum: [Link](https://www.alzforum.org/research-models/sorl1a528tapoe4trem2r47h) toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Mike Sasner strainDetails: [View](https://www.jax.org/strain/031940) targetedGenes: SORL1 APOE TREM2 backgroundStrain: C57BL/6J alzforumInformation: [View](https://www.alzforum.org/research-models/sorl1a528tapoe4trem2r47h)