url: http://labs.neuroscience.mssm.edu/project/friedel-lab/ grant: U01AG046170 program: AMP-AD species: Mouse summary: This strain carries a TAU tg and a targeted ko of the Plexin-B1 gene. The Plexin-B1 gene was knocked out by targeted insertion of a gene trap cassette into the gene (JAX-MGI allele Plxnb1<tm1Matl>).The Plexin-B1 gene was identified through analysis of co-expression modules in subtypes of AD as a potential driver gene in AD. These mice will be useful in studying the pathophysiology of Alzheimer�s disease in the context of disrupted Plexin-B1 function. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Roland Friedel strainDetails: [View](http://labs.neuroscience.mssm.edu/project/friedel-lab/) targetedGenes: MAPT PLXNB1