url: http://labs.neuroscience.mssm.edu/project/friedel-lab/ grant: U01AG046170 program: AMP-AD species: Mouse summary: This model has an APP/PS1 tg and a targeted ko mutation of the Plexin-B1. The Plexin-B1 gene was knocked out by targeted insertion of a gene trap cassette into the gene (JAX-MGI allele Plxnb1<tm1Matl>).Plexin-B1 was identified through analysis of co-expression modules in subtypes of AD as a potential driver in AD. Mice will be useful in studying the pathophysiology of AD in the context of disrupted Plexin-B1. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Roland Friedel strainDetails: [View](http://labs.neuroscience.mssm.edu/project/friedel-lab/) targetedGenes: APP PSEN1 PLXNB1