Bin1 intron 1 SNP_hAbeta_APOE4_Trem2.R47H

syn22251841

Created By Mette Peters Mette

url: https://www.jax.org/strain/033869
grant: U54AG054345
program: MODEL-AD
summary: This model expresses a CRISPR/cas9-generated KI of an AD non-coding risk variant (C>A) between ex1 and ex2 in the Bin1 gene modeling the rs10194375 risk SNP. This is expressed on a sensitized model also expressing: a humanized APOE4 KI; a CRISPR/Cas9-generated App allele with a humanized Abeta1-42 region-G601R, F606Y, R609H in the mouse gene, corresponding to amino acid positions 676, 681, 684 in the human APP locus, and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene.
toolType: Mouse Model
modelType: Late Onset Alzheimer's disease
strainDetails: [View](https://www.jax.org/strain/033869)
targetedGenes: BIN1 APP APOE TREM2
backgroundStrain: C57BL/6J

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