url: https://www.jax.org/strain/034415 grant: U54AG054345 program: MODEL-AD summary: This model expresses exons 2-4 of the human APOE gene knocked into the mouse Apoe locus; the Alzheimer’s disease risk variant APOE4 is expressed in place of the mouse gene. In addition, a CRISPR/Cas9-generated App allele with a humanized Abeta1-42 region (G601R, F606Y, R609H in the mouse gene, corresponding to amino acid positions 676, 681, 684 in the human APP locus) is also expressed. toolType: Mouse Model modelType: Late Onset Alzheimer's disease strainDetails: [View](https://www.jax.org/strain/034415) targetedGenes: APOE APP backgroundStrain: C57BL/6J