url: https://www.jax.org/strain/032759 grant: U54AG054345 program: MODEL-AD summary: CRISPR/Cas9 was used to engineer a point mutation (GCC-ACC) into the mouse Sorl1 gene to create the A528T amino acid substitution. This models a common, highly conserved missense variant (rs2298813) that is significantly associated with late-onset AD. Overexpression of the missense variant rs2298813 leads to elevated Ab42 secretion. toolType: Mouse Model modelType: Late Onset Alzheimer's disease strainDetails: [View](https://www.jax.org/strain/032759) targetedGenes: SORL1 backgroundStrain: C57BL/6J