url: https://www.jax.org/strain/033868 grant: U54AG054345 program: MODEL-AD summary: This is a KO of a 2kB region in the Adamts4 locus deleting a region with motifs homologous to two regulatory SNPs-rs4575098; rs11585858 that have been identified as AD risk SNPs and eQTLs for FCER1G expression. This was created on a sensitized model expressing: a hu APOE4 KI; a CRISPR/Cas9-generated App allele with a hu Abeta1-42 region (G601R, F606Y, R609H in the mo gene, corresponding to as positions 676 681 684 in the hu APP locus) and a CRISPR/cas9 R47H point mutation in the mo Trem2 gene. toolType: Mouse Model modelType: Late Onset Alzheimer's disease strainDetails: [View](https://www.jax.org/strain/033868) targetedGenes: ADAMTS4 APOE APP TREM2 backgroundStrain: C57BL/6J
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