url: https://www.jax.org/strain/033875 grant: U54AG054345 program: MODEL-AD summary: This model has an engineered synonymous coding SNP (GCG-GCT at amino acid 24) in ex1 of the Epha1 locus, to model the rs12703524 SNP that has been associated with LOAD risk. This was created on a sensitized model expressing: a humanized APOE4 knock-in; a CRISPR/Cas9-generated App allele with a humanized Abeta1-42 region-G601R, F606Y, R609H in the mouse gene, corresponding to aa positions 676, 681, 684 in the human APP locus and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. toolType: Mouse Model modelType: Late Onset Alzheimer's disease strainDetails: [View](https://www.jax.org/strain/033875) targetedGenes: EPHA1 APOE APP TREM2 backgroundStrain: C57BL/6J
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