url: https://www.jax.org/strain/032774 grant: U54AG054345 program: MODEL-AD summary: Amino acids at positions 85-88 in the Pilra locus were edited from GEFI to RQSF to model the AD risk variant rs1859788 and humanize the surrounding region. This was created on a sensitized model expressing: a humanized APOE4 knock-in; a CRISPR/Cas9-generated App allele with a humanized Abeta1-42 region (G601R, F606Y, R609H in the mouse gene, corresponding to as positions 676, 681, 684 in the human APP locus) and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. toolType: Mouse Model modelType: Late Onset Alzheimer's disease strainDetails: [View](https://www.jax.org/strain/032774) targetedGenes: PILRA APOE APP TREM2 backgroundStrain: C57BL/6J
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