url: https://www.jax.org/strain/034037 grant: U54AG054349 program: MODEL-AD summary: Picalm*H465R is a CRISPR/Cas9 generated mutant of the phosphatidylinositol binding clathrin assembly protein gene carrying the H465R mutation that corresponds to the human H458R mutation associated with Alzheimer's Disease (AD). These mice may be useful in pre-clinical studies of AD. toolType: Mouse Model modelType: Late Onset Alzheimer's disease contributor: Grant MacGregor availableData: PicalmH458R strainDetails: [View](https://www.jax.org/strain/034037) targetedGenes: Picalm backgroundStrain: C57BL/6J mouseModelReport: [View](https://www.synapse.org/#!Synapse:syn25474067)