url: https://www.jax.org/strain/030674 grant: U54AG054345 program: MODEL-AD summary: CRISPR/Cas9 was used to engineer a point mutation (ATG->TTG) into the mouse Plcg2 locus to create the M28L amino acid substitution. This models the rare PLCG2 risk variant (rs61749044). This is expressed on a sensitized model also expressing a humanized APOE4 knock-in and a CRISPR/cas9-generated R47H point mutation in the mouse Trem2 gene. toolType: Mouse Model modelType: Late Onset Alzheimer's disease availableData: Plcg2M28LSNP strainDetails: [View](https://www.jax.org/strain/030674) targetedGenes: Plcg2 backgroundStrain: C57BL/6J.APOE4/Trem2*R47H