DOI: 10.1093/nar/gkt838 year: 2014 study: EpiGABA title: Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites. grants: R21MH103877 authors: Kozlenkov A, Roussos P, Timashpolsky A, Barbu M, Rudchenko S, Bibikova M, Klotzle B, Byne W, Lyddon R, Di Narzo AF, Hurd YL, Koonin EV, Dracheva S journal: Nucleic acids research abstract: We applied Illumina Human Methylation450K array to perform a genomic-scale single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily glial) nuclei separated from the orbitofrontal cortex of postmortem human brain. The findings were validated using enhanced reduced representation bisulfite sequencing. We identified thousands of sites differentially methylated (DM) between neuronal and nonneuronal cells. The DM sites were depleted within CpG-island-containing promoters pubmedId: 24057217 entity_name: Kozlenkov Nucleic acids research 2014 (Pubmed ID 24057217)
Drop files to upload
Kozlenkov Nucleic acids research 2014 (Pubmed ID 24057217) page is loading…