DOI: 10.1186/s13059-019-1805-1 year: 2019 study: LIBD-WGBS title: Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation. grants: R21MH102791 authors: Price AJ, Collado-Torres L, Ivanov , Xia W, Burke EE, Shin JH, Tao R, Ma L, Jia Y, Hyde TM, Kleinman JE, Weinberger DR, Jaffe AE journal: Genome biology abstract: DNA methylation (DNAm) is a critical regulator of both development and cellular identity and shows unique patterns in neurons. To better characterize maturational changes in DNAm patterns in these cells, we profile the DNAm landscape at single-base resolution across the first two decades of human neocortical development in NeuN+ neurons using whole-genome bisulfite sequencing and compare them to non-neurons (primarily glia) and prenatal homogenate cortex. We show that DNAm changes more dramatica pubmedId: 31554518 entity_name: Price Genome biology 2019 (Pubmed ID 31554518)
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