DOI: 10.1126/science.aat8127 year: 2019 study: UCLA-ASD Capstone Collection BrainGVEX title: Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. grants: R01MH094714 U01MH103340 P50MH106934 UO1MH103339 U01MH103346 R21MH103877 U01MH103392 U01MH103392 U01MH103365 R01MH094714 U01MH103339 U01MH103340 R01MH110920 authors: Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE, Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH journal: Science (New York N.Y.) abstract: Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments of transcriptomic organization in diseased brains are limited. In this work, we integrated genotypes and RNA sequencing in brain samples from 1695 individuals with autism spectrum disorder (ASD), schizophrenia, and bipolar disorder, as well as controls. More than 25% of the transcriptome exhibits differential splicing or ex pubmedId: 30545856 entity_name: Gandal Science (New York, N.Y.) 2019 (Pubmed ID 30545856)
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