DOI: 10.1038/nn.4373 year: 2017 study: UCLA-ASD title: Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder. grants: R01MH094714 authors: Wu YE, Parikshak NN, Belgard TG, Geschwind DH journal: Nature neuroscience abstract: Genetic variants conferring risk for autism spectrum disorder (ASD) have been identified, but the role of post-transcriptional mechanisms in ASD is not well understood. We performed genome-wide microRNA (miRNA) expression profiling in post-mortem brains from individuals with ASD and controls and identified miRNAs and co-regulated modules that were perturbed in ASD. Putative targets of these ASD-affected miRNAs were enriched for genes that have been implicated in ASD risk. We confirmed regulatory pubmedId: 27571009 entity_name: Wu Nature neuroscience 2017 (Pubmed ID 27571009)
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